International Journal of Science and Technology

International Journal of Science and Technology>> Volume 7, Number 6, June 2017

International Journal of Science and Technology


Renal and Hepatocellular Effects of Chronic Red Palm Oil Consumption

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Author Ekpo G. I., Johnson, J. T., Hemen, T. J., Odey, M. O., Luke, U.O., Eyo, R.A., Ambo, E.E.
On Pages 539-542
Volume No. 2
Issue No. 8
Issue Date August, 2012
Publishing Date August, 2012
Keywords Renal, Hepatic, chronic consumption, red palm oil.


Abstract

The effect of chronic consumption of red palm oil on renal and hepatic toxicity on albino wistar rats was evaluated. The design consisted of 5 study groups of 8 rats each. Group A were fed on rat chow supplemented with 10% oxidised palm oil, group B received rat chow supplement with 10% freshly prepared palm oil, while group C were fed on rat chow supplemented with 20% oxidised palm oil, group D were fed with rat chow supplemented with 20% freshly prepared palm oil and only rat pellets were given to group E which served as the control. The feeding lasted for a period of three months (90 days) after which blood and tissues were obtained for evaluation of renal and hepatic indices. ALP activity in groups A, B, C and D were significantly (p < 0.05) higher compared to the control. However, the serum ALT activities showed a significant (p < 0.05) decrease in group A, B and C compared to the control. Moreso, AST activities of group A, C and D recorded significant (p < 0.05) decrease while that of group B showed a significant (p < 0.05) increase compared to the control. However, the renal total protein of group A, B and D showed significant (p < 0.05) decrease while the renal total cholesterol of group C showed a significant (p < 0.05) increase and that of group D showed a significant (p < 0.05) decrease compared to the control. Nevertheless, the renal triacylglyceride of the entire treated groups compared well to each other except for group D which showed significant (p < 0.05) decrease compared to the control. Finally, this study showed that palm oil - depending on the source - especially oxidized palm oil may have some deleterious effects on hepatic and renal tissues and is a called for concern.

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