International Journal of Science and Technology

International Journal of Science and Technology>> Volume 7, Number 9, September 2017

International Journal of Science and Technology


Effect of Aqueous Extract of Moringa Oleifera on Serum Protein of Trypanosoma Brucei- Infected Rats

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Author Edoga C. O., Njoku O. O., Amadi E. N., Afomezie P. I.
On Pages 85-87
Volume No. 3
Issue No. 1
Issue Date January, 2013
Publishing Date January, 2013
Keywords Moringa oleifera, Trypanosoma brucei, Hypoproteinaemia, Rattus norvegicus.


Abstract

We have investigated the effect of aqueous extract of Moringa oleifera leaves on the serum protein of trypanosome —infected rats. Sixty Parasite free-albino rats were used, which were divided into four groups. Two groups of rats were intraperitoneally injected with Trypanosoma brucei. One group was administered with the aqueous extract in drinking water; the remaining infected group was left untreated. Data from these groups were compared with those of two groups of healthy rats, one of which was similarly treated with the aqueous extract. The experiment was terminated 16 days post-infection (pi). Analyses of the sera using Bradford method and cellulose acetate electrophoresis showed that aqueous extract of Moringa oleifera influenced the state of hypoproteinaemia in the trypanosome infected rats. This was manifested by a positive increase in the level of total serum protein concentration, albumin and beta-globulin.The extract also delayed the proliferation of the parasites associated with trypanosomiasis. Our results support the potent antioxidant activity of aqueous extract of Moringa oleifera which adds one more positive attribute to its known pharmacological importance.

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