International Journal of Science and Technology

International Journal of Science and Technology>> Volume 7, Number 6, June 2017

International Journal of Science and Technology


Phytochemical Screening and in Vivo Antitrypanosomal Activity of Methanol Extracts of Peristrophe Bicalyculata in Mice Infected With Trypanosoma Evansi

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Author Awulu, E. A., Oniye S. J., Adelanwa M. A.
On Pages 34-39
Volume No. 3
Issue No. 1
Issue Date January, 2013
Publishing Date January, 2013
Keywords Trypanosomiasis, chemotherapy, Trypanosoma evansi, Peristrophe bicalyculata, curative, suppressive.


Abstract

There is the urgent need for therapeutic agents that are more effective, accessible and affordable to Africans who bears the burden of most diseases since chemotherapy of African trypanosomiasis remains far from being satisfactory. The qualitative and quantitative analysis of the Methanol extracts of Peristrophe bicalyculata showed the presence of oxalate, phytate, saponins, cyanogenic glycosides, alkaloids, and flavonoids, with 0.12mg/100g, 59.5mg/100g, 2%, 960mg/100g, 15%, 0.42% compositions respectively. The LD50 was determined to be below 1500mg/kg body weight. The methanol extract at doses of 400mg/kg body weight and 500mg/kg body weight were found to have some curative properties and at doses of 300mg/kg body weight and 400mg/kg body weight were found to have some suppressive properties in mice infected with Trypanosoma evansi . This potency of the extract when compared to the standard drug (Diaminazine aceterate) was less effective but significant reduction was observed when compared with the control (untreated).

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