International Journal of Science and Technology

International Journal of Science and Technology>> Volume 7, Number 9, September 2017

International Journal of Science and Technology

The Roles of Dietary Vitamins A and D Supplements in Treatment of Hypoproteinamia Induced by Trypanosoma Brucei Infected Rats

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Author(s) Edoga, C.O., Njoku O.O., Okeke J. J., Afomezie P. I.
On Pages 296-299
Volume No. 3
Issue No. 5
Issue Date May, 2013
Publishing Date May, 2013
Keywords Vitamin A, Vitamin D, Trypanosoma brucei, and Rattus norvegicus.


The roles of dietary vitamins A and D supplements in the treatment of hypoproteinamia induced by Trypanosoma brucei infected rats were studied. The rats were inoculated with trypanosomes intraperitoneally and samples were collected on fourth, eight, twelfth and sixteenth days of post infection. The experiment was carried out at the Department of Biochemistry, Nnamdi Azikiwe University Awka. Seventy five parasite free-albino rats were used, which were divided into five groups. Group A (control) was left uninfected with trypanosomes, group B and C were infected vitamins A and D per kg of feed respectively, group D was infected with trypanosomes and treated with 30mls of vitamin A plus 30mls of vitamin D and group E was infected and left untreated. Analyses of sera using Bradford method and cellulose acetate electrophoresis showed that vitamins A and D influenced the state of hypoproteinamia in the trypanosome - infected rats. This was manifested by a positive increase in the level of total serum protein concentration, albumin and beta-globulin concentration. The vitamins also delayed the proliferation of the parasites associated with trypanosomiasis.

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